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The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study
Julius E Oben*1, Judith L Ngondi1, Claudia N Momo1, Gabriel A Agbor1,2
and Caroline S Makamto Sobgui1,2
Address: 1Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, B.P. 812, University of Yaoundé 1, Yaoundé, Cameroon and 2CRPMT, Institute of Medicinal Plants Studies, Yaoundé, Cameroon
Email: Julius E Oben* - moc.liamtoh|nebosuiluj#moc.liamtoh|nebosuiluj; Judith L Ngondi - moc.oohay|idnognlj#moc.oohay|idnognlj; Claudia N Momo - rf.oohay|aidualc_omom#rf.oohay|aidualc_omom; Gabriel A Agbor - rf.oohay|eagoga#rf.oohay|eagoga; Caroline
Abstract
Aim: To evaluate the effects of two formulations, Cissus quadrangularis-only and a Cissus
quadrangularis/Irvingia gabonensis combination, on weight loss in overweight and obese human
subjects.
Methods: The study was a 10 week randomized, double-blind, placebo-controlled design involving 72 obese or overweight participants (45.8% male; 54.2% female; ages 21–44; mean age = 29.3). The participants were randomly divided into three equal (n = 24) groups: placebo, Cissus quadrangularisonly, and Cissus quadrangularis/Irvingia gabonensis combination. Capsules containing the placebo or active formulations were administered twice daily before meals; no major dietary changes nor exercises were suggested during the study. A total of six anthropomorphic and serological measurements (body weight, body fat, waist size; total plasma cholesterol, LDL cholesterol, fasting blood glucose level) were taken at baseline and at 4, 8 and 10 weeks.
Results: Compared to the placebo group, the two active groups showed a statistically significant difference on all six variables by week 10. The magnitude of the differences was noticeable by week 4 and continued to increase over the trial period.
Conclusion: Although the Cissus quadrangularis-only group showed significant reductions on all
variables compared to the placebo group, the Cissus quadrangularis/Irvingia gabonensis combination resulted in even larger reductions. This apparently synergistic formulation should prove helpful in the management of obesity and its related complications.
Published: 31 March 2008
Lipids in Health and Disease 2008, 7:12 doi:10.1186/1476-511X-7-12
Received: 17 February 2008
Accepted: 31 March 2008
This article is available from: http://www.lipidworld.com/content/7/1/12
© 2008 Oben et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License [http://creativecommons.org/licenses/by/2.0]
Please note: This work is provided on this website for informational purposes. The conclusions therein do not necessarily reflect the views of Ground Up Strength.
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